Achieving its stated clinical goal.
Demonstrated under optimal circumstances in a prospective randomized controlled trial (RCT) but the results are limited to the study subjects.
Producing greater benefit than harm
Assessed under ordinary circumstances in the more general population, often by way of an observational yet analytic longitudinal cohort study.
Health status improvement for a given amount of resources ($) expended.
Determined via a cost-effectiveness analysis or cost-utility analysis