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A peptic ulcer is a nonmalignant, mucosal lesion of the stomach or duodenum in which acid and pepsin play major pathogenic roles. The major forms of peptic ulcer are duodenal ulcer (DU) and gastric ulcer (GU).
If the natural banks of a river are broken, the breach may be filled with concrete along with reinforcement of the riverbed using concrete and construction of a dam upstream to control the flow of water. Similarly, the medical management of ulcer should not be based on a simple cause-effect relationship. Treatment should be adjusted to individual patients and should be designed by taking the involvement of many causative factors (including H. pylori and stress) into consideration. In other words, the bio-psycho-social approach is essential for the treatment of peptic ulcer.