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Outcomes Measures, Pharmacoeconomics and Pharmacoepidemiology, Ad-Hoc Data Source, Record Linkage System, Cost effective analysis.
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First, let's define what QALYs are. QALYs are a measure of health outcomes that takes into account both the quantity and the quality of life lived. The basic idea is that a year of perfect health is worth 1 QALY, while a year of less than perfect health is worth less than 1 QALY. The quality of life is measured using a utility score, which ranges from 0 (equivalent to being dead) to 1 (equivalent to perfect health).

To illustrate how QALYs are calculated, let's consider a hypothetical patient who is being treated for a chronic condition. We'll assume that the patient is 50 years old and has a life expectancy of 30 years. We'll also assume that the patient's utility score is 0.7 (i.e., the patient's quality of life is 70% of perfect health).

Now, let's consider two different treatment options for this patient. Treatment A costs $10,000 per year and is expected to extend the patient's life by 5 years, with a utility score of 0.8. Treatment B costs $20,000 per year and is expected to extend the patient's life by 10 years, with a utility score of 0.6.

To calculate the QALYs for each treatment option, we first multiply the number of years by the utility score to get the number of QALYs for each year. For Treatment A, we get:

5 years x 0.8 utility score = 4 QALYs

For Treatment B, we get:

10 years x 0.6 utility score = 6 QALYs

Next, we add up the total number of QALYs for each treatment option and divide by the total cost to get the cost-effectiveness ratio:

Treatment A: 4 QALYs / $10,000 = 0.4 QALYs per $1,000
Treatment B: 6 QALYs / $20,000 = 0.3 QALYs per $1,000

In this example, Treatment B is more cost-effective than Treatment A, as it produces more QALYs per dollar spent. However, it's important to note that the decision about which treatment option to choose may depend on other factors, such as the patient's preferences and values, as well as the availability of alternative treatments.
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