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Treatment Guidelines - Hospital Institutional Guidelines, Standard Treatment Guidelines, WHO Guidelines, Disease Treatment Guidelines and etc
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Depression treatment guidelines

American Psychiatric Association (APA) Guidelines for the Treatment of Major Depressive Disorder (2023 Update):

Acute Phase Treatment:


  • First-line treatments: Psychotherapy (e.g. cognitive-behavioral therapy, interpersonal therapy) and/or antidepressant medication (e.g. SSRIs, SNRIs, bupropion).
  • For moderate-severe depression, combination of psychotherapy and medication is recommended.
    For milder depression, either psychotherapy or medication can be used as initial treatment


Continuation Phase Treatment:

Continue effective acute phase treatment for 4-9 months to prevent relapse.

Maintenance Phase Treatment:

For patients at high risk of recurrence, long-term (>1 year) maintenance treatment with medication and/or psychotherapy is recommended.


American Psychiatric Association (APA)

The American Psychiatric Association's guidelines for treating depression provide evidence-based recommendations to help clinicians manage this common and serious mental health condition. These guidelines aim to improve the quality of care and outcomes for patients with major depressive disorder.

Key aspects of the APA depression guidelines include:

Diagnostic criteria and assessment, Treatment planning and selection, Pharmacotherapy recommendations, Psychotherapy approaches, Combination treatments, Management of treatment-resistant depression.


National Institute for Health and Care Excellence (NICE) Guidelines for the Treatment of Depression in Adults (2022 Update):

The National Institute for Health and Care Excellence (NICE) Guidelines for the Treatment of Depression in Adults provide evidence-based recommendations for the management of depression in the United Kingdom's healthcare system. These guidelines aim to standardize and improve the quality of care for adults experiencing depressive episodes. They cover a range of interventions, from initial assessment and diagnosis to various treatment options and long-term management strategies. The NICE guidelines emphasize a stepped-care approach, where treatment intensity is matched to the severity of depression and patient needs. They also stress the importance of patient choice, collaborative decision-making, and the integration of both pharmacological and psychological interventions. Regular updates to these guidelines ensure that they reflect the most current research and clinical evidence, helping healthcare professionals provide effective, patient-centered care for individuals with depression.

Click the below links to access:

Depression in adults: treatment and management


Depression in children and young people: identification and management


Depression in adults with a chronic physical health problem: recognition and management

Canadian Network for Mood and Anxiety Treatments (CANMAT) Guidelines (2022 Update):

Similar to APA and NICE guidelines, recommends a combination of psychotherapy and pharmacotherapy as first-line. Provides more detailed recommendations on specific antidepressant classes and psychotherapy modalities. Includes guidance on managing treatment-resistant depression.

American College of Physicians (ACP)

The American College of Physicians (ACP) depression treatment guidelines provide evidence-based recommendations for the management of major depressive disorder in adults. These guidelines aim to assist primary care physicians and other healthcare providers in making informed decisions about the diagnosis and treatment of depression. The ACP guidelines emphasize a patient-centered approach, considering factors such as symptom severity, patient preferences, and potential side effects of interventions. They cover various treatment options, including pharmacotherapy, psychotherapy, and combination treatments, and provide guidance on when to consider each approach. The guidelines also address important aspects of depression management, such as initial assessment, treatment selection, and monitoring of treatment response. By offering a systematic framework for depression care, the ACP guidelines seek to improve the quality and consistency of treatment for patients with major depressive disorder in primary care settings.


World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines (2021 Update):

Comprehensive international guidelines covering acute, continuation, and maintenance treatment. Provides evidence-based recommendations on pharmacotherapy, psychotherapy, neurostimulation, and other somatic treatments. Addresses special populations like elderly, adolescents, and those with comorbidities.

Click the below links to access:

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders. Part 2: Maintenance Treatment of Major Depressive Disorder-Update 2015


World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1: Update 2013 on the acute and continuation treatment of unipolar depressive disorders


World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders in Primary Care


French Association for Biological Psychiatry and Neuropsychopharmacology

The French Association for Biological Psychiatry and Neuropsychopharmacology (AFPBN) has developed guidelines for the treatment of depression that provide evidence-based recommendations for clinicians in France and French-speaking regions. These guidelines offer a comprehensive approach to managing depressive disorders, incorporating the latest research and clinical expertise.

Key features of the AFPBN depression treatment guidelines include:

Diagnostic criteria and assessment procedures, Treatment strategies for various types and severities of depression, Recommendations for pharmacotherapy, including antidepressant selection, Guidance on psychotherapeutic interventions, Management of treatment-resistant cases, Considerations for special populations (e.g., elderly, pregnant women).

The guidelines aim to standardize care while allowing for personalized treatment approaches. They emphasize the importance of regular monitoring and adjustment of treatment plans based on patient response.


American Academy of Child & Adolescent Psychiatry

The American Academy of Child & Adolescent Psychiatry (AACAP) has developed comprehensive guidelines for the treatment of depression in children and adolescents. These guidelines provide evidence-based recommendations to assist clinicians in diagnosing and managing depressive disorders in young patients. They emphasize a multimodal approach, combining psychotherapy, pharmacotherapy, and family interventions as appropriate. The guidelines cover various aspects of care, including initial assessment, treatment planning, and ongoing management. They stress the importance of tailoring interventions to the individual needs of each young patient, considering factors such as age, developmental stage, and severity of symptoms. The AACAP guidelines also address special considerations for this age group, such as the role of family involvement, school-based interventions, and the management of comorbid conditions. Regular updates ensure that these guidelines reflect the latest research and best practices in pediatric and adolescent mental health care.

Click below to access the links:

Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Major and Persistent Depressive Disorders


Practice Parameter for the Assessment and Treatment of Children and Adolescents With Depressive Disorders



Institute for Clinical Systems Improvement

The Institute for Clinical Systems Improvement (ICSI) has developed comprehensive guidelines for the treatment of depression in adults. These guidelines provide evidence-based recommendations to assist healthcare providers in delivering effective, patient-centered care. The ICSI depression treatment guidelines cover various aspects of depression management, including screening, diagnosis, treatment planning, and ongoing care. They emphasize a collaborative care model, integrating primary care and behavioral health services to ensure comprehensive treatment. The guidelines outline a stepped approach to care, matching treatment intensity to the severity of depression and patient needs. They incorporate both pharmacological and non-pharmacological interventions, including psychotherapy, lifestyle modifications, and self-management strategies. The ICSI guidelines also address the importance of patient education, shared decision-making, and regular follow-up to monitor treatment progress and adjust interventions as needed. By providing a structured yet flexible framework for depression management, these guidelines aim to improve patient outcomes and standardize care across different healthcare settings.


American Academy of Pediatrics

The American Academy of Pediatrics (AAP) depression treatment guidelines provide comprehensive recommendations for identifying and managing depression in children and adolescents. These guidelines emphasize the importance of early detection, accurate diagnosis, and evidence-based interventions tailored to young patients. The AAP advocates for a multi-faceted approach, combining psychotherapy, particularly cognitive-behavioral therapy (CBT), with pharmacological treatments when appropriate. The guidelines stress the crucial role of primary care pediatricians in screening, diagnosing, and managing mild to moderate depression, while recommending collaboration with mental health specialists for more severe cases. They also highlight the significance of family involvement, ongoing monitoring, and suicide risk assessment throughout the treatment process. By providing a structured framework for depression management in youth, the AAP guidelines aim to improve outcomes and quality of life for affected children and adolescents.

Click below to access the links:

Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management


Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part II. Treatment and Ongoing Management



The National Centre of Excellence in Youth Mental Health

The National Centre of Excellence in Youth Mental Health, also known as Orygen in Australia, has developed comprehensive guidelines for the treatment of depression in young people. These guidelines provide evidence-based recommendations specifically tailored to the unique needs of adolescents and young adults. They emphasize early intervention, personalized care, and a holistic approach to treatment that considers the developmental stage and social context of young people. The guidelines cover various aspects of care, including assessment, psychosocial interventions, pharmacotherapy, and ongoing management. They also address the importance of involving family members and caregivers in the treatment process. By focusing on youth-specific strategies, these guidelines aim to improve outcomes, reduce the long-term impact of depression, and promote better mental health for young people transitioning into adulthood.


Veterans Affairs/Department of Defense

The Veterans Affairs/Department of Defense (VA/DoD) Clinical Practice Guideline for the Management of Major Depressive Disorder provides evidence-based recommendations for the care of veterans and active-duty service members experiencing depression. These guidelines are tailored to the unique needs and challenges faced by military personnel and veterans, taking into account factors such as combat exposure, post-traumatic stress, and the transition to civilian life. The VA/DoD guidelines cover a comprehensive range of topics, including screening, assessment, treatment planning, and various intervention strategies. They emphasize a patient-centered approach, incorporating both pharmacological and non-pharmacological treatments, and address specific considerations for this population, such as suicide risk assessment and management. Regular updates ensure that these guidelines reflect the latest research and best practices in depression care, aiming to improve outcomes and quality of life for those who have served in the military.


World Health Organization (WHO) mhGAP Intervention Guide (2016):


Provides evidence-based guidelines for the management of depression and other mental, neurological, and substance use disorders in low- and middle-income countries. Recommends a combination of psychosocial interventions and, if necessary, antidepressant medication as first-line treatment.


Royal Australian and New Zealand College of Psychiatrists (RANZCP) Clinical Practice Guidelines for Mood Disorders (2020):

Emphasize a holistic, person-centered approach to the management of depression, including lifestyle interventions, psychotherapy, and pharmacotherapy. Provide guidance on the use of antidepressants, management of treatment-resistant depression, and the role of brain stimulation therapies.


European Psychiatric Association (EPA) - Guidance on the Treatment of Major Depressive Disorder

Provides evidence-based recommendations on the treatment of major depressive disorder, focusing on pharmacotherapy and psychotherapy, including specific guidance for special populations.

Guidance Papers

EPA Guidance Papers aim to improve the quality of mental health care in Europe by disseminating written information based on best evidence and psychiatric practice and to facilitate countries learning from each other in areas where guidelines are lacking.


Guideline Development Group (GDG) - National Guidelines for the Management of Depression in Primary and Secondary Care

Part of the NICE guidelines but more focused on implementation in primary and secondary care settings, emphasizing early recognition and management.


International Society for Nutritional Psychiatry Research

The International Society for Nutritional Psychiatry Research (ISNPR) has developed guidelines for the treatment of depression that emphasize the role of nutrition and lifestyle factors in mental health. These guidelines recognize the growing body of evidence linking diet, nutrition, and metabolic health to the development and treatment of depression. The ISNPR recommendations focus on integrating nutritional interventions alongside conventional treatments, highlighting the potential of dietary modifications, specific nutrient supplementation, and lifestyle changes in managing depressive symptoms. These guidelines aim to provide clinicians with evidence-based strategies to address nutritional factors that may contribute to or exacerbate depression, offering a more holistic approach to treatment. By incorporating nutritional psychiatry principles, the ISNPR guidelines seek to enhance the efficacy of depression treatment and improve overall patient outcomes.


Indian Psychiatric Society (IPS) - Clinical Practice Guidelines for Depression

The Indian Psychiatric Society (IPS) Clinical Practice Guidelines for Depression provide a comprehensive framework for the diagnosis and management of depression in the Indian context. These guidelines are tailored to address the unique cultural, social, and economic factors that influence mental health care in India. They offer evidence-based recommendations for clinicians, covering various aspects of depression management, including assessment, diagnosis, pharmacological and non-pharmacological interventions, and follow-up care. The IPS guidelines emphasize the importance of a holistic approach, integrating biological, psychological, and social perspectives in treatment. They also consider the challenges of implementing mental health care in diverse settings across India, from urban centers to rural areas with limited resources. By providing standardized, culturally sensitive recommendations, these guidelines aim to improve the quality of care for individuals with depression throughout the country.


National Health Mission

The National Health Mission (NHM) depression treatment guidelines provide a framework for managing depression in India's public health system. These guidelines aim to standardize and improve the quality of care for individuals with depression across the country, particularly in rural and underserved areas. They emphasize early detection, proper assessment, and evidence-based interventions tailored to the Indian context. The NHM guidelines promote a stepped-care approach, integrating both non-pharmacological and pharmacological treatments. They also focus on capacity building of primary healthcare workers, community engagement, and reducing stigma associated with mental health issues. By addressing depression as a significant public health concern, these guidelines seek to enhance access to mental health services and improve overall health outcomes within the broader mission of the National Health Mission.
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